Image distributor

The Female Prostate – Kekereke

The Female Prostate

prostateContrary to the statement by Borchert et al that “Women have no prostate..,” women do have a prostate, the presence of which has clinical significance for the female and for our understanding of the expression of prostate- specific antigen (PSA) in women and its possible implications.

In 1672 the anatomist Regnier de Graaf described and illustrated a set of glands and ducts surrounding the female urethra that he called the female prostate. Subsequently, in 1880, Alexander Skene redirected attention to this structure, particularly to two paraurethral ducts (Skene’s ducts) therein, and emphasized their importance in infection of the female genitalia.

Skene’s paraurethral glands and ducts are homologous to the maleprostate (2). Recent studies supporting this homology, as reviewed by Zaviačič et al. (3,4), are postmortem and detailed histological examinations of the urethras of 130 women, followed by biochemical and immunohistochemical studies that demonstrated expression of PSA and prostate-specific acid phosphatase (PSAP) in Skene’s paraurethral glands and ducts. These studies unequivocally substantiate the existence of the female prostate.male female prostate

The female homologue of the male prostate is of clinical significance not only as a focus for acute and chronic infection, but also as the origin of other pathologic entities, including adenocarcinoma (3,4), a cancer which shows, as does its male counterpart, localized expression of PSA and PSAP(3,4).

Thus, there is convincing evidence that prostatic tissue exists in the female, and that the term “female prostate” is both fully justified and preferable to the terminology Skene’s glands and ducts. The latter incorrectly implies that some other structure of an extraprostatic nature, rather than the prostate itself, is involved. If the female prostate exhibits the immuno permissiveness observed in the male prostate (5), it may also serve as a site for viral latency and origin of infection in women with human immunodeficiency virus.

Of perhaps equal importance is the expression of PSA (6). The existence in women of the counterpart of the male prostate, shown to express PSA, may provide a note of caution in considering the molecular basis of the apparent anomalous expression of PSA in male and female nonprostatic tissues, e.g., in female breast (1). Given observations on the association of PSA detection in breast cancer with steroid hormonereceptor positive tumors, one may envision (6) the existence of a complex regulatory gene network controlling the expression of PSA in several organs. Therefore, a given tissue (depending on the state of cellular differentiation) may express previously repressed genes after neoplastic transformation. Also, and not mutually exclusive, somatic mutations may lead to specific changes in PSA genes in cancer cell clones (6). productoverview

Consider also, as initially pointed out by Longo (7), the forensic implications for alleged cases of rape. In the absence of knowledge of the female prostate and of the possible presence of PSA and PSAP in the normal female ejaculatory fluid, the identification of these supposedly male-specific markers in vaginal secretions may have been “. . . a fait accompli” (7) to the accused, but possibly innocent, perpetrator. Indeed, judicial miscarriage may have easily occurred when, for example, PSAP has been considered adequate for the identification of sperm spots and its potential origin from the prostate of the female victim was not taken intoaccount. Therefore, the presence of PSA and/or PSAP for the confirmation of spermatic secretion in the absence of spermatozoa has no forensic value. This knowledge of PSAP originating from the female ejaculate was instrumental in the recent acquittal of an alleged rapist in Europe. In this regard, forensic DNA analysis can be expected to play a significant role in the near future.

  1. Milan Zaviačič and
  2. Richard J. Ablin

+Author Affiliations

  1. Institute of Pathology, Comenius University School of Medicine, Bratislava, Slovakia
  2. Innapharma, Inc., Upper Saddle River, NJ
  1. Correspondence to: Richard J. Ablin, Ph.D., Innapharma, Inc., 10 Mountainview Road, Suite 301, Upper Saddle River, NJ 07458.

ajax loader - The Female Prostate - Kekereke

17 thoughts on “The Female Prostate – Kekereke”

  1. MothmanboBby says:

    This is my first time visiting your blog and I am very fascinated. Many thanks for sharing and keep up 😉

  2. WilliamDug says:

    I love everything you post. You’ve done great job

  3. Robertjal says:

    Awesome site, how do u get all this information?I have read a couple of articles on your site and I really like your style. Thanks a million, keep up the great work.

  4. CharlieBeway says:

    Wonderful website, how do you find all this information?I’ve read a couple of posts on your website and I like your style. Thanks a million, keep up the great work.

  5. EfrainRak says:

    It is a very good post. This website is loaded with lots of interesting things, it helped me in many ways.

  6. Georgeduert says:

    Thank you for the site, it’s full of a lot of handy info. This helped me a lot.

  7. Sheryllep says:

    I read through this amazing site and you have so much handy information, bookmarked 🙂

  8. ShakitaCag says:

    It’s a good article. This website has lots of interesting things, it made it easier for me in many ways.

  9. Robertjal says:

    It is my very first time visiting your blog and I am very fascinated. Thank you for sharing and keep up 😉

  10. CharlieBeway says:

    it’s a really great site!So much helpful info and handy suggestions, thanks a lot =)

  11. EfrainRak says:

    Thanks for a really great blog. It was actually very useful. I am so glad I found this.

  12. Sheryllep says:

    I am amazed. I do not think I’ve met anyone who knows just as much about this as you do. You should make a career of it, honestly, amazing site

  13. MothmanboBby says:

    Awesome site, how do u find all this info?I’ve read through a few posts on your site and I love your writing style. Thanks a million, keep up the good work.

  14. WilliamDug says:

    Many thanks for a really impressive blog. It was actually very helpful. I am so glad I discovered this.

  15. EfrainRak says:

    I have discovered loads of useful information on your site this page in particular. Many thanks for sharing.

Leave a Reply

Your email address will not be published. Required fields are marked *

Translate »