The Female Prostate – Kekereke
The Female Prostate
Contrary to the statement by Borchert et al that “Women have no prostate..,” women do have a prostate, the presence of which has clinical significance for the female and for our understanding of the expression of prostate- specific antigen (PSA) in women and its possible implications.
In 1672 the anatomist Regnier de Graaf described and illustrated a set of glands and ducts surrounding the female urethra that he called the female prostate. Subsequently, in 1880, Alexander Skene redirected attention to this structure, particularly to two paraurethral ducts (Skene’s ducts) therein, and emphasized their importance in infection of the female genitalia.
Skene’s paraurethral glands and ducts are homologous to the maleprostate (2). Recent studies supporting this homology, as reviewed by Zaviačič et al. (3,4), are postmortem and detailed histological examinations of the urethras of 130 women, followed by biochemical and immunohistochemical studies that demonstrated expression of PSA and prostate-specific acid phosphatase (PSAP) in Skene’s paraurethral glands and ducts. These studies unequivocally substantiate the existence of the female prostate.
The female homologue of the male prostate is of clinical significance not only as a focus for acute and chronic infection, but also as the origin of other pathologic entities, including adenocarcinoma (3,4), a cancer which shows, as does its male counterpart, localized expression of PSA and PSAP(3,4).
Thus, there is convincing evidence that prostatic tissue exists in the female, and that the term “female prostate” is both fully justified and preferable to the terminology Skene’s glands and ducts. The latter incorrectly implies that some other structure of an extraprostatic nature, rather than the prostate itself, is involved. If the female prostate exhibits the immuno permissiveness observed in the male prostate (5), it may also serve as a site for viral latency and origin of infection in women with human immunodeficiency virus.
Of perhaps equal importance is the expression of PSA (6). The existence in women of the counterpart of the male prostate, shown to express PSA, may provide a note of caution in considering the molecular basis of the apparent anomalous expression of PSA in male and female nonprostatic tissues, e.g., in female breast (1). Given observations on the association of PSA detection in breast cancer with steroid hormonereceptor positive tumors, one may envision (6) the existence of a complex regulatory gene network controlling the expression of PSA in several organs. Therefore, a given tissue (depending on the state of cellular differentiation) may express previously repressed genes after neoplastic transformation. Also, and not mutually exclusive, somatic mutations may lead to specific changes in PSA genes in cancer cell clones (6).
Consider also, as initially pointed out by Longo (7), the forensic implications for alleged cases of rape. In the absence of knowledge of the female prostate and of the possible presence of PSA and PSAP in the normal female ejaculatory fluid, the identification of these supposedly male-specific markers in vaginal secretions may have been “. . . a fait accompli” (7) to the accused, but possibly innocent, perpetrator. Indeed, judicial miscarriage may have easily occurred when, for example, PSAP has been considered adequate for the identification of sperm spots and its potential origin from the prostate of the female victim was not taken intoaccount. Therefore, the presence of PSA and/or PSAP for the confirmation of spermatic secretion in the absence of spermatozoa has no forensic value. This knowledge of PSAP originating from the female ejaculate was instrumental in the recent acquittal of an alleged rapist in Europe. In this regard, forensic DNA analysis can be expected to play a significant role in the near future.
- © 1998 Oxford University Press
- Milan Zaviačič and
- Richard J. Ablin⇓
- Institute of Pathology, Comenius University School of Medicine, Bratislava, Slovakia
- Innapharma, Inc., Upper Saddle River, NJ
- Correspondence to: Richard J. Ablin, Ph.D., Innapharma, Inc., 10 Mountainview Road, Suite 301, Upper Saddle River, NJ 07458.
Sexual Biology: 2. Female Prostatic Ejaculation – Kekereke
This video discusses the biology of female prostatic ejaculation, one of four possible sources of female orgasmic discharge. It shows both the location and a close up of the female prostate and compares it with the male prostate. The female prostate is still referred to as paraurethral glands by less modern Ob/Gyns and Urologists. In 2002, The Federative International Committee on Anatomical Terminology agreed to support the term “female prostate’, in lieu of “peraurethral glands,” or “Skene’s Glands.”
This gland(s) produces PSA just like the male prostate. The throbbing flow, in sync with orgasmic muscle contractions, is about 5 ml in volume, milky and the taste may vary with the time of the woman’s menstrual cycle. All forms of female ejaculation or emission , are far more pleasurable than not ejaculating on orgasm from what I have been told. Although one woman told me this always happened from the first time she masturbated. She wouldn’t know, having no comparison to a lesser pleasure.
The biological mechanism of ejaculation is unknown in both male and female. One investigator proposes it is due to a build up of endorphins (natural morphine) that triggers the response in both male and female orgasms. That explains the greater pleasure.